Brand: Altra Health Inc.
Product Code: Product 3
Availability: Out Of Stock
$39.95
Potential benefitsAnti-cancer
Lowers blood pressure
Decreases cholesterol
Hepato-protective
Enhances immune system function
Lowers blood glucose/anti-dibetic
Anti-inflammatory
How to take MaitakeAdding 1 teaspoon (~2 grams) of Altra Health Maitake Powder into water, tea, juice, smoothie, or other favorite food every day. We recommend you take one gram for general health maintenance and 2-3 grams for the treatment of an ailment.
It鈥檚 recommended that you follow these steps for 30-90 days to ensure that you are giving the active components enough time to take effectiveness.
StorageStore in a cool dry place and out of direct sunlight.

What is Maitake?

It is also known as the "hen of the woods", "sheep's head", "king of mushrooms" (due to its large size), and "cloud mushroom". The Latin name is Grifola frondosa, referring to the mythical griffin. It is a basidiomycetes fungus in the Polyporaceae family (synonym, Polyporus frondosus Dicks. ex Fries). Maitake grows in clusters near the foot of oak trees and can reach 50 cm in base diameter. One bunch can weigh up to 45 kg (100 lbs). Maitake has a rippling, flowery appearance resembling dancing butterflies, hence one of its common names, dancing mushroom.
The polysaccharide beta-glucan is present in low quantities (0% to 0.2%) in most of the mushrooms in the Polyporaceae family (eg, reishi mushroom) and possesses antitumor activity. The D fraction of beta-glucan appears to be the most active and potent form of the polysaccharide, a protein-bound extract developed in Japan. An MD-fraction has now been described, as well, with purportedly superior activity. Both structure-functional relationship and fractionation by anion exchange chromatography of beta-glucan have been reported.
Neutral, acidic, and water-soluble polysaccharides have been extracted from maitake, and their structure has been determined. Two different glycan conformations have been obtained from the plant. The beta-1,3-glycan grifolan conformation has been elucidated using magnetic resonance spectroscopy.
Ascorbic acid analog and glycoside studies have been reported. A lectin from maitake has been isolated and characterized. In addition, a grifolisin enzyme and the enzyme phytase have been described, and lysophosphatidylethanolamine has been identified in studies examining apoptosis in neuronal cells.
Structural characterization of maitake extract constituents and carbon-13 nuclear magnetic resonance analysis of the fruit body's constituents have been conducted.

Why Choose Canadian Wild Maitake?

Altra Maitake grows wild in eastern Canada, and is certified Organic.

Maitake Health Benefits

Maitake has been used for its antiviral action and to treat cancer, diabetes, high blood pressure, cholesterol, and obesity.

The major functions include below but not limited to
Immunostimulant/Anticancer

Immunostimulant activity is a characteristic of many medicinal mushrooms, including shiitake, suchirotake, or kawaratake, that are used clinically as anticancer drugs in Japan. [1] Maitake's polysaccharide may be slightly different from the beta-glucans found in other fungi. The large molecular weight of the polysaccharide molecule and branch structure configurations may be important for its antitumor or immunostimulant effect. [2-4] In 1998, the US Food and Drug Administration approved an Investigational New Drug Application for a phase 2 pilot study on the effect of maitake D-fraction on advanced breast and prostate cancers. [1]
Maitake extract has been studied in mouse and in vitro studies involving Escherichia coli . [5] It activates macrophages; [6-7] enhances cytokine, natural killer, and cytotoxic-T cell production; [1, 6] has antigen-specific antibody response; and is an immunostimulant protecting against toxicity of chemotherapeutic agents. [8-10]
Maitake demonstrated antitumor activity in mouse experiments, [11-13] while in other experiments it exhibited synergism with coadministered chemotherapeutic agents. [9] Other experiments failed to show direct antitumor action. [9] Prevention of metastasis by maitake has been demonstrated in mice. [14]
Some pharmacokinetic parameters of beta-D-glucan have been evaluated in mice. [15] Experiments have attempted to evaluate dose-dependent anti-tumor activity as well as route, timing, and other factors. [16-19]
Clinical case studies of liver, lung, stomach, breast, brain, and prostate cancers involving the use of maitake have been reported. [1]
In a study of 165 patients, results suggested that quality of life indicators had improved. Of these patients, 90% reported an improvement in cancer-treatment symptoms (eg, nausea, hair loss) and 83% reported pain reduction. [20]

Antidiabetic

When maitake powdered fruit body was administered orally to genetically diabetic mice, blood glucose reduction was observed compared with a control group. [21] Maitake may control blood glucose levels by possible reduction of insulin resistance and enhancement of insulin sensitivity. [1]

Antihypertensive

Hypertensive rats given 5% maitake mushroom powder had a reduction in blood pressure. [22-23] Similar blood pressure-lowering activity was seen in another study performed in rats, in which maitake extract lowered blood pressure from 200 to 115 mm Hg in 4 hours. [24] In an unpublished human trial, 11 patients with documented essential hypertension took 500 mg maitake mushroom tablets twice daily. A mean decrease in diastolic blood pressure of approximately 8 mm Hg and a mean decrease in systolic blood pressure of about 14 mm Hg were reported. [25]

Anticholesterol

Hypertensive rats given 5% maitake mushroom powder had a reduction in blood pressure. [22-23] Similar blood pressure-lowering activity was seen in another study performed in rats, in which maitake extract lowered blood pressure from 200 to 115 mm Hg in 4 hours. [24] In an unpublished human trial, 11 patients with documented essential hypertension took 500 mg maitake mushroom tablets twice daily. A mean decrease in diastolic blood pressure of approximately 8 mm Hg and a mean decrease in systolic blood pressure of about 14 mm Hg were reported. [25]

Antiobesity

At least 2 studies are available concerning maitake's antiobesity activity. After 18 weeks, overweight rats fed unheated maitake powder lost weight compared with controls. [28] In an observational study, 30 patients lost between 3 and 12 kg (7 and 26 lbs) after administration of 20 to 500 mg tableted maitake powder per day for 2 months. [29]

Antiviral

In an in vitro study, the D-fraction of maitake exhibited an inhibitory action on the hepatitis B virus alone and a synergistic action with interferon alpha-2b. [30]
A human trial of poor methodology attempted to demonstrate a positive effect on CD4+ count and viral load. In 35 HIV-positive patients given maitake powder and DM-fraction extract over 12 months, 85% reported an increased sense of well-being. The effect of maitake on CD4+ count and viral load was minimal. [31]

References

[1] Mayell M . Maitake extracts and their therapeutic potential . Altern Med Rev . 2001;6:48-60.
[2] Adachi K , Ohno N , Ohsawa M , Sato K , Oikawa S , Yadomae T . Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan 鈥済rifolan LE鈥� from Grifola frondosa . Chem Pharm Bull . 1989;37:1838-1843.
[3] Adachi K , Ohno N , Ohsawa M , Yadomae T . Change of biological activities of (1----3)-beta-D-glucan from Grifola frondosa upon molecular weight reduction by heat treatment . Chem Pharm Bull . 1990;38:477-481.
[4] Ohno N , Asada N , Adachi Y , Yadomae T . Enhancement of LPS triggered TNF-alpha (tumor necrosis factor-alpha) production by (1-->3)-beta-D-glucans in mice . Biol Pharm Bull . 1995;18:126-133.
[5] Jin ZC , Qian J . Inhibitory effects of fifty kinds of herbal drugs, vegetables and chemicals SOS response [in Chinese] . Zhonghua Yu Fang Yi Xue Za Zhi . 1994;28:147-150.
[6] Adachi Y , Okazaki M , Ohno N , Yadomae T . Enhancement of cytokine production by macrophages stimulated with (1-->3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa . Biol Pharm Bull . 1994;17:1554-1560.
[7] Ohno N , Egawa Y , Hashimoto T , Adachi Y , Yadomae T . Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice . Biol Pharm Bull . 1996;19:608-612.
[8] Wu MJ , Cheng TL , Lian TW , Wang L , Chiou SY . Immunomodulatory properties of Grifola frondosa in submerged culture . J Agric Food Chem . 2006;54:2906-2914.
[9] Kodama N , Murata Y , Asakawa A , et al. Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice . Nutrition . 2005;21:624-629.
[10] Lin H , Chcung SW , Nesin M , Cassileth BR , Cunningham-Rundles S . Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production . Clin Vaccine Immunol . 2007;14:21-27.
[11] Lin JT , Liu WH . o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis . J Agric Food Chem . 2006;54:7564-7569.
[12] Adachi K , Nanba H , Kuroda H . Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake) . Chem Pharm Bull . 1987;35:262-270.
[13] Suzuki I , Itani T , Ohno N , et al. Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice . J Pharmacobiodyn . 1985;8:217-226.
[14] Nanba H . Activity of maitake D-fraction to inhibit carcinogenesis and metastasis . Ann N Y Acad Sci . 1995;768:243-245.
[15] Miura NN , Ohno N , Aketagawa J , Tamura H , Tanaka S , Yadomae T . Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice . FEMS Immunol Med Microbiol . 1996;13:51-57.
[16] Suzuki I , Itani T , Ohno N , et al. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa . J Pharmacobiodyn . 1984;7:492-500.
[17] Hishida I , Nanba H , Kuroda H . Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake) . Chem Pharm Bull . 1988;36:1819-1827.
[18] Suzuki I, Takeyama T, Ohno N . Antitumor effect of polysaccharide grifolan NMF-5N on syngeneic tumor in mice . J Pharmacobiodyn . 1987;10:72-77.
[19] Ohno N , Adachi Y , Suzuki I . Antitumor activity of a beta-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa . J Pharmacobiodyn . 1986;9:861-864.
[20] Nanba H . Townsend Lett Doct Patient . 1996;84-85.
[21] Kubo K , Aoki H , Nanba H . Anti-diabetic activity present in the fruit body of Grifola frondosa (maitake): I . Biol Pharm Bull . 1994;17:1106-1110.
[22] Kabir Y , Yamaguchi M , Kimura S . Effect on shiitake ( Lentius edodes ) and maitake ( Grifola frondosa ) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats . J Nutr Sci Vitaminol . 1987;33:341-346.
[23] Kabir Y , Kimura S . Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR) . J Nutr Sci Vitaminol . 1989;35:91-94.
[24] Adachi K , Nanba H , Otsuka M , Kuroda H . Blood pressure-lowering activity present in the fruit body of Grifola frondosa (maitake): I . Chem Pharm Bull . 1988;36:1000-1006.
[25] Gerson S . (Director of the Foundation for Holistic Medical Research in NYC). 1994 (unpublished).
[26] Kubo K , Nanba H . The effect of maitake mushrooms on liver and serum lipids . Altern Ther Health Med . 1996;2:62-66.
[27] Kubo K , Nanba H . Anti-hyperliposis effect of maitake fruit body ( Grifola frondosa ): I . Biol Pharm Bull . 1997;20:781-785.
[28] Ohtsuru M . Anti-obesity activity exhibited by orally administered powder of maitake mushrooms ( Grifola frondosa ) [in Japanese]. Anshin . 1992:198-200.
[29] Yokota M . Observatory trial at anti-obesity activity of maitake mushrooms ( Grifola frondosa ) [in Japanese]. Anshin . 1992:202-204.
[30] Gu CQ , Li JW , Chao FH . Inhibition of hepatitis B virus by D-fraction from Grifola frondosa : synergistic effect of combination with interferon-alpha in HepG2 2.2.15 . Antiviral Res . 2006;72:162-165.
[31] Nanba H . Effects of Maitake ( Grifola frondosa ) glucan in HIV-infected patients. Mycoscience . 2000;41:293-295.

Maitake Side Effects and Considerations

If you have diabetes, you should consult your doctor before ingestion. Maitake may have an effect on your blood sugar. It may also lower your blood pressure, so be sure to discuss your options with your doctor if you have hypotension.
You shouldn鈥檛 ingest maitake mushroom within two weeks of surgery or if you have a bleeding disorder.

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